Thermo Fisher Scientific PDE6G Monoclonal Antibody (OTI1E11), TrueMAB
인간 PDE6G 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 유세포분석에 최적화됨. TrueMAB 포맷으로 고순도 친화 크로마토그래피 정제. 안정한 액상 형태로 -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E11 |
| Immunogen | Full length human recombinant protein of human PDE6G produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The second messengers cAMP and cGMP are key regulatory molecules involved in diverse signal transduction pathways. Their levels are controlled by synthesis (nucleotide cyclases) and hydrolysis (cyclic nucleotide phosphodiesterases, PDEs).
PDEs catalyze the conversion of cyclic nucleotides to nucleoside monophosphates. PDE6 acts as the effector enzyme in the G protein-mediated visual signal transduction cascade.
PDE6 consists of multiple subunits: rod and cone-specific catalytic subunits (alpha’, alpha, beta), inhibitory subunit gamma, and delta of unknown function. The catalytic core forms alpha’/alpha’ homodimers in cones and alpha/beta heterodimers in rods.
C-terminal modifications such as methylation, myristoylation, and prenylation are essential for complex assembly and membrane association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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