ELK Biotechnology NuMA (phospho-Thr2055) rabbit pAb

제품명

NuMA (phospho-Thr2055) rabbit pAb

대체명

Nuclear mitotic apparatus protein 1 (NuMA protein), SP-H antigen

적용 분야

• Western Blot (WB)

권장 희석 배율

• WB: 1:1000–2000

면역원

• Synthesized phospho peptide around human NuMA (Thr2055)

저장 조건

• -20°C, 1년 안정성

클론 특성

• Clonality: Polyclonal
• Isotype: IgG
• Concentration: 1 mg/ml

관찰 밴드

• 240 kDa

유전자 정보

세포 내 위치

Nucleus, nucleoplasm, nucleus matrix, chromosome, cytoplasm (cytoskeleton, microtubule organizing center, centrosome, spindle pole, cell cortex), cell membrane (lipid-anchor, cytoplasmic side), lateral cell membrane.
Mitotic cell cycle-dependent shuttling protein that relocalizes from the interphase nucleus to the spindle poles and cell cortex (PubMed:1541636, PubMed:10811826). Localization to the spindle poles is regulated by AAAS (PubMed:26246606).
In interphase, resides in the nuclear matrix (PubMed:1541630, PubMed:1541636, PubMed:23921553). In prophase, restricted to the interchromatin or condensed chromosome space (PubMed:10811826). In prometaphase, after nuclear envelope disassembly, forms aggregates.

배경 정보

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

종 반응성

• Human
• Rat
• Mouse