ELK Biotechnology p63 (phospho-Ser160/162) rabbit pAb
p63 단백질의 Ser160/162 인산화 상태를 검출하는 rabbit polyclonal 항체로, WB에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며 핵 내 발현 단백질 분석에 유용합니다. 피부 발달, 줄기세포 조절, DNA 손상 반응 연구에 활용 가능합니다.
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제품명
p63 (phospho-Ser160/162) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Tumor protein 63 (p63), Chronic ulcerative stomatitis protein (CUSP), Keratinocyte transcription factor KET, Transformation-related protein 63 (TP63), Tumor protein p73-like (p73L), p40, p51 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human p63 (Ser160 and Ser162) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 63 kDa |
| Gene ID (Human) | 8626 |
| Human Swiss-Prot No. | Q9H3D4 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human, Rat, Mouse |
Background
Tumor protein p63 (TP63) is a member of the p53 family of transcription factors. These proteins contain an N-terminal transactivation domain, a central DNA-binding domain, and an oligomerization domain. Alternative splicing and promoter usage produce multiple isoforms with distinct functional properties. p63 isoforms are involved in skin development and maintenance, adult stem/progenitor cell regulation, heart development, and aging processes. Certain isoforms protect the germline by eliminating oocytes or testicular germ cells with DNA damage. Mutations in TP63 are associated with ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, and ADULT syndrome (acro-dermato-ungual-lacrimal-tooth syndrome).
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