ELK Biotechnology PACRG rabbit pAb
PACRG rabbit pAb는 인간 및 생쥐 시료에 반응하는 폴리클로날 항체로, WB 분석에 적합합니다. 인간 PACRG 유래 펩타이드로 면역화되었으며, 고순도 IgG 형태로 제공됩니다. 파킨 유전자와 공동 조절되는 PACRG 단백질 연구에 유용합니다.
- 판매단위
- pk
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PACRG rabbit pAb
Supplier: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PACRG rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human PACRG (AA range: 18–68) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Storage | -20°C / 1 year |
| GeneID (Human) | 135138 |
| Human Swiss-Prot No | Q96M98 |
| Cellular Localization | nucleus, mitochondrion, cytosol, integral component of membrane, vesicle, neuron projection, cell body, sperm midpiece |
Background
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson’s disease. These genes are co-regulated in various tissues and share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson’s disease patients and suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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