ELK Biotechnology PAK1/2 (phospho-Ser199/204) rabbit pAb
PAK1/2 인산화(Ser199/204) 특이적 rabbit polyclonal 항체로, 세포 이동성과 형태 조절에 관련된 단백질 인식에 사용. WB 분석에 적합하며, 인간·마우스·랫트에서 반응. 고순도 IgG, -20°C에서 1년 보관 가능.
- 판매단위
- pk
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제품명
PAK1/2 (phospho-Ser199/204) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 serine/threonine p21-activating kinase (PAK) 계열 단백질 중 PAK1/2의 인산화된 Ser199 및 Ser204 부위를 인식하는 rabbit polyclonal antibody입니다. 세포 이동성, 형태 및 신호 전달 연구에 활용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Alternative Names | Serine/threonine-protein kinase PAK1 (EC 2.7.11.1), Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human PAK1 (Ser199 and Ser204) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 5058 |
| Human Swiss-Prot No | Q13153 |
| Species Reactivity | Human, Mouse, Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, cell junction (focal adhesion), cell projection (lamellipodium, ruffle membrane, invadopodium), nucleus (nucleoplasm), chromosome, centrosome.
Colocalizes with RUFY3, F-actin and other migration components in invadopodia at the cell periphery (PubMed:25766321).
Recruited to the cell membrane via interaction with CDC42 and RAC1, and to focal adhesions upon activation.
Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin.
Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 and co-recruited with MORC2 on damaged chromatin (PubMed:23260667).
Localization to the centrosome does not depend on phosphorylation state.
Background
This gene encodes a member of the serine/threonine p21-activating kinases (PAK family). PAK proteins are critical effectors linking RhoGTPases to cytoskeletal reorganization and nuclear signaling, serving as targets for small GTP-binding proteins Cdc42 and Rac.
This family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Apr 2010).
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