ELK Biotechnology PCDA1 rabbit pAb
PCDA1 rabbit pAb는 인간, 쥐, 생쥐 시료에서 WB 분석에 적합한 다클론 항체입니다. 인간 PCDA1 펩타이드(AA 102-152)로부터 유래하였으며, 세포막 단백질 검출에 활용됩니다. 고순도 IgG 형태로 1 mg/ml 농도, -20°C에서 1년 보관 가능합니다.
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제품명
PCDA1 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Protocadherin alpha-1 (PCDH-alpha-1) |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human PCDA1 (AA 102–152) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 105 kD |
| GeneID (Human) | 56147 |
| Human Swiss-Prot No | Q9Y5I3 |
| Species Reactivity | Human, Rat, Mouse |
| Storage Conditions | -20°C (1 year) |
| Host Species | Rabbit |
| Cellular Localization | Isoform 1: Cell membrane, single-pass type I membrane protein; Isoform 2: Secreted |
Background
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.
The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences.
The tandem array of 15 N-terminal exons (variable exons) are followed by downstream C-terminal exons (constant exons) shared by all genes in the cluster.
The large, uninterrupted N-terminal exons each encode six cadherin ectodomains, while the C-terminal exons encode the cytoplasmic domain.
These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins likely playing a critical role in the establishment and function of specific cell-cell connections in the brain.
Alternative splicing has been observed, and additional variants have been suggested, but their full-length nature has yet to be determined.
[Provided by RefSeq, Jul 2008]
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