ELK Biotechnology PCDA3 rabbit pAb
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| Product name: | PCDA3 rabbit pAb |
| Alternative Names: | Protocadherin alpha-3 (PCDH-alpha-3) |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500-2000 |
| Immunogen: | Synthesized peptide derived from human PCDA3 AA range: 750-800 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 105kD |
| GeneID（Human）: | 56145 |
| Human Swiss-Prot No: | Q9Y5H8 |
| Cellular localization: | Cell membrane ; Single-pass type I membrane protein . |
| Background: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Rat;Mouse; |
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