ELK Biotechnology PCDA3 rabbit pAb
Protocadherin alpha-3(PCDA3)를 인식하는 rabbit polyclonal antibody로, WB에 적합합니다. 인간, 랫트, 마우스 시료에서 반응하며 세포막 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
PCDA3 rabbit pAb
제품 개요
Protocadherin alpha-3(PCDH-alpha-3)를 인식하는 rabbit polyclonal antibody입니다. 주로 Western blot(WB) 분석에 사용되며, 인간, 랫트, 마우스 시료에서 반응합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PCDA3 rabbit pAb |
| Alternative Names | Protocadherin alpha-3 (PCDH-alpha-3) |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human PCDA3 (AA range: 750–800) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 105 kDa |
| Gene ID (Human) | 56145 |
| Human Swiss-Prot No. | Q9Y5H8 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome 5 that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons (variable exons) are followed by downstream C-terminal exons (constant exons), which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
[provided by RefSeq, Jul 2008]
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