ELK Biotechnology PCDAB rabbit pAb
Protocadherin alpha-11(PCDAB)을 인식하는 토끼 폴리클로날 항체. WB에 적합하며 1:500–2000 희석 권장. 인간, 생쥐, 랫트 시료에 반응. 세포막 단일 통과형 단백질 검출에 유용. -20°C에서 1년 보관 가능.
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제품명
PCDAB rabbit pAb
대체명
Protocadherin alpha-11 (PCDH-alpha-11)
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human PCDAB (AA range: 96–146) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 105 kD |
| Gene ID (Human) | 56138 |
| Human Swiss-Prot No. | Q9Y5I1 |
| Species Reactivity | Human, Rat, Mouse |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
배경 (Background)
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.
The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster.
The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain.
Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
[provided by RefSeq, Jul 2008]
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