ELK Biotechnology PDGFRb (Phospho-Tyr857) rabbit pAb
PDGFRb (Phospho-Tyr857) 인산화 부위를 인식하는 토끼 폴리클로날 항체로, IHC, IF, WB에 적합합니다. 세포막 및 세포소기관에 위치한 PDGFRβ 단백질 검출에 사용됩니다. 고순도 IgG, 1 mg/ml 농도로 제공되며, -20°C에서 1년 보관 가능합니다.
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PDGFRb (Phospho-Tyr857) rabbit pAb
제품 개요
PDGFRb (Phospho-Tyr857) rabbit pAb는 인간 PDGFRβ 단백질의 인산화된 Tyr857 부위를 인식하는 폴리클로날 항체입니다. 세포막 및 세포 내 소기관에서 PDGFRβ의 발현 및 활성 상태를 분석하는 데 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PDGFRb (Phospho-Tyr857) rabbit pAb |
| Alternative Names | Platelet-derived growth factor receptor beta (PDGF-R-beta; PDGFR-beta; EC 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD antigen CD140b) |
| Applications | IHC, IF, WB |
| Recommended Dilutions | IHC-p: 1:50–200, WB: 1:500–2000 |
| Immunogen | Synthesized peptide derived from human PDGFRb (Phospho-Tyr857) |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 135–180 kDa |
| Gene ID (Human) | 5159 |
| Human Swiss-Prot No. | P09619 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasmic vesicle; Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. |
| Storage | -20°C, 1 year |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
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