ELK Biotechnology PKM2 (phospho-Tyr105) rabbit pAb
PKM2 (phospho-Tyr105) rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 다클론 항체입니다. WB, ELISA, IHC에 적합하며, Tyr105 인산화 부위를 인식합니다. 세포 내 PKM2 단백질의 발현 및 위치 연구에 유용합니다.
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- ES14088-xxxxx (2개 옵션)
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제품명
PKM2 (phospho-Tyr105) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40), Cytosolic thyroid hormone-binding protein (CTHBP), Opa-interacting protein 3 (OIP-3), Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1 (THBP1), Tumor M2-PK, p58 |
| Applications | WB, ELISA, IHC |
| Recommended Dilutions | WB: 1:500–2000; IHC-p: 1:50–300; ELISA: 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human PKM2 (Tyr105) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kDa |
| Gene ID (Human) | 5315 |
| Human Swiss-Prot No. | P14618 |
| Species Reactivity | Human, Mouse, Rat |
세포 내 위치 (Cellular Localization)
- Isoform M2: Cytoplasm, Nucleus.
Translocates to the nucleus in response to various signals such as EGF receptor activation or apoptotic stimuli (PubMed:17308100, 22056988, 24120661).
Nuclear translocation is promoted by acetylation by EP300 (PubMed:24120661).
Deacetylation by SIRT6 promotes nuclear export via XPO4, suppressing transcriptional activation and tumorigenesis (PubMed:26787900). - Isoform M1: Cytoplasm.
Background
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate.
It interacts with thyroid hormone and may mediate metabolic effects induced by thyroid hormones.
This protein also binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence and invasion of human cells, suggesting a role in bacterial pathogenesis.
Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
[Provided by RefSeq, May 2011]
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