ELK Biotechnology PSA6 rabbit pAb
PSA6 단백질을 인식하는 토끼 다클론 항체로 WB에 적합. 인간, 마우스, 랫트 시료에 반응. 합성 펩타이드 면역원 사용. 핵과 세포질에서 발현되는 PSA6 단백질 검출에 활용 가능. -20°C에서 1년 보관.
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제품명
PSA6 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human PSA6 (AA range: 70–120) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5687 |
| Human Swiss-Prot No. | P60900 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Cytoplasm, Nucleus. Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). |
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
This gene encodes a member of the peptidase T1A family that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome.
[provided by RefSeq, Aug 2013]
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