ELK Biotechnology PSA7 rabbit pAb
PSA7 rabbit pAb는 인간, 마우스, 랫트에 반응하는 다클론 항체로 WB 및 IHC에 적합합니다. PSA7 단백질의 168-218번 아미노산 서열에서 유래한 합성 펩타이드를 면역원으로 사용합니다. -20°C에서 1년 보관 가능하며, 세포질과 핵에서 발현되는 PSA7 단백질 검출에 활용됩니다.
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제품명
PSA7 rabbit pAb
적용 분야
- WB (Western Blot)
- IHC (Immunohistochemistry)
권장 희석 배율
- WB: 1:500–2000
- IHC-p: 1:50–300
제품 정보
| 항목 | 내용 |
|---|---|
| Immunogen | Synthesized peptide derived from human PSA7 (AA range: 168–218) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 5688 |
| Human Swiss-Prot No | O14818 |
| Cellular Localization | Cytoplasm, Nucleus. Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. |
| Species Reactivity | Human, Mouse, Rat |
배경 (Background)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator.
The 20S core comprises four rings of 28 non-identical subunits — two rings of seven alpha subunits and two rings of seven beta subunits.
Proteasomes are distributed throughout eukaryotic cells at high concentration and cleave peptides in an ATP/ubiquitin-dependent process via a non-lysosomal pathway.
This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit.
The encoded protein interacts with the hepatitis B virus X protein and regulates hepatitis C virus internal ribosome entry site (IRES) activity, essential for viral replication.
It also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha.
A pseudogene of this gene is located on the long arm of chromosome 9.
[provided by RefSeq, Jul 2012]
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