ELK Biotechnology PSB10 rabbit pAb
PSB10 단백질을 인식하는 토끼 다클론 항체로, WB 및 IHC 분석에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포질 및 핵에 위치한 단백질 검출에 활용됩니다. 고순도 IgG 형식으로 -20°C에서 장기 보관 가능합니다.
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제품명
PSB10 rabbit pAb
제품 개요
PSB10 단백질을 인식하는 토끼 유래 다클론 항체로, Western blot(WB) 및 면역조직화학(IHC) 분석에 적합합니다. 인간, 마우스, 랫트 시료에서 사용 가능하며, 세포질 및 핵에 존재하는 PSB10 단백질의 검출에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human PSB10 (AA range: 78–128) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5699 |
| Human Swiss-Prot No. | P40306 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
배경(Background)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of four rings of 28 non-identical subunits; two rings are composed of seven alpha subunits and two rings are composed of seven beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. (RefSeq, Jul 2008)
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