ELK Biotechnology PSB3 rabbit pAb
PSB3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC 분석에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포질 및 핵에서 발현되는 PSB3 단백질 검출에 사용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
PSB3 rabbit pAb
제품 개요
PSB3 단백질을 인식하는 토끼 유래 폴리클로날 항체로, Western Blot(WB) 및 Immunohistochemistry(IHC) 분석에 적합합니다. 세포질 및 핵에서 발현되는 PSB3 단백질의 위치 및 발현 연구에 활용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human PSB3 (AA range: 41–91) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5691 |
| Human Swiss-Prot No. | P49720 |
| Cellular Localization | Cytoplasm, Nucleus. Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. |
| Species Reactivity | Human; Mouse; Rat |
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of four rings of 28 non-identical subunits; two rings are composed of seven alpha subunits and two rings are composed of seven beta subunits. Proteasomes are distributed throughout eukaryotic cells at high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
This gene encodes a member of the proteasome B-type family (T1B family), a 20S core beta subunit. The 26S proteasome may be involved in trinucleotide repeat expansion, associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants (RefSeq, Sep 2013).
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