ELK Biotechnology PSME1 rabbit pAb
PSME1 단백질을 인식하는 ELK Biotechnology의 rabbit polyclonal antibody로, WB에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도 IgG 형태로 -20°C에서 1년간 안정 저장 가능합니다. 26S 프로테아솜 복합체 연구에 활용됩니다.
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제품명
PSME1 rabbit pAb
제품 개요
ELK Biotechnology에서 제공하는 PSME1 rabbit polyclonal antibody는 인간, 마우스, 랫트에서 반응하며, 26S proteasome 복합체 연구에 적합합니다. 단백질 발현 검출용으로 Western blot(WB) 실험에 사용됩니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human PSME1 (AA range: 60–110) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5720 |
| Human Swiss-Prot No. | Q06323 |
| Cellular Localization | Proteasome complex, nucleoplasm, cytoplasm, cytosol, proteasome activator complex, extracellular exosome |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
배경 정보
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes, a 20S core and a 19S regulator. The 20S core consists of four rings of 28 non-identical subunits (two rings of seven alpha and two rings of seven beta subunits). The 19S regulator includes a base (six ATPase and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
A modified proteasome, the immunoproteasome, processes class I MHC peptides and contains an alternate regulator, 11S regulator (PA28), replacing the 19S regulator.
Three subunits (alpha, beta, gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits induced by gamma-interferon. Three alpha and three beta subunits form a heterohexameric ring. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Jul 2013]
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