ELK Biotechnology Rad17 (phospho-Ser635) rabbit pAb

제품명

Rad17 (phospho-Ser635) rabbit pAb

제품 설명

Rad17 (phospho-Ser635) 항체는 DNA 손상 반응 및 세포 주기 조절 연구에 사용되는 rabbit polyclonal antibody입니다. 인간, 쥐, 마우스 시료에서 반응하며, Western blot, ELISA, IHC 등 다양한 응용에 적합합니다.

제품 스펙

Background

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC) and can form a complex with RFCs. It binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene encode distinct protein isoforms.