ELK Biotechnology REN3A rabbit pAb
REN3A 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 IHC에 사용 가능. 핵과 세포질 간 이동 단백질 검출에 적합. 사람, 쥐, 생쥐 시료에 반응하며, -20°C에서 1년 보관 가능.
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ELK Biotechnology REN3A rabbit pAb
제품 설명
REN3A 단백질을 인식하는 토끼 폴리클로날 항체로, mRNA 핵 내 수출 및 감시 복합체 관련 연구에 사용됩니다. 이 단백질은 핵과 세포질 사이를 이동하며, 비정상적인 mRNA를 감지하여 NMD(nonsense-mediated mRNA decay)를 유도하는 역할을 합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | REN3A rabbit pAb |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human REN3A (AA range: 190–240) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 65110 |
| Human Swiss-Prot No. | Q9H1J1 |
| Cellular Localization | Nucleus, Cytoplasm; shuttling between nucleus and cytoplasm |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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