
ELK Biotechnology RFX6 rabbit pAb
RFX6 단백질을 인식하는 토끼 다클론 항체로, WB, ELISA, IHC에 적합. 인간 및 생쥐 시료에 반응하며, β세포 분화 관련 연구에 유용. -20°C에서 1년 보관 가능.
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RFX6 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | RFX6 rabbit pAb |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from human RFX6 (AA range: 264–314) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 222546 |
| Human Swiss-Prot No | Q8HWS3 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus restricting the expression of beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.
[provided by RefSeq, Sep 2010]
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