Thermo Fisher Scientific DLAT Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
LAIGASEDKL VPADNEKGFD VASMMSVTLS CDHRVVDGAV GAQWLAEFRK YLE

Target Information

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC).
PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A.
The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A.

Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies, which are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.