Thermo Fisher Scientific SOX17 Monoclonal Antibody (OTI2F9), TrueMAB

Applications

Tested Dilution

Publications

ELISA (ELISA)

1:100-1:1,000

-

Luminex (LUM)

1:100-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI2F9

Immunogen

Human recombinant protein fragment corresponding to amino acids 177-414 of human SOX17 produced in E.coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SOX17,uniProtId:Q9H6I2-1,ncbiNodeId:9606,antigenRange:177-414,antigenLength:414,antigenImageFileName:TA600123_SOX17_Q9H6I2-1_House_mouse.svg,antigenImageFileNamePDP:TA600123_SOX17_Q9H6I2-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

View additional formats

• Biotin
• Request custom conjugation

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with <5% trehalose

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Target Information

SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors. It acts as a transcription regulator that binds target promoter DNA and bends the DNA. It binds to the sequences 5-AACAAT-3 or 5-AACAAAG-3. SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. It promotes degradation of activated CTNNB1. SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic hear tube and for normal development of the definitive gut endoderm. Mutations in the gene can result in vesicoureteral reflux.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.