Thermo Fisher Scientific SIRT1 Polyclonal Antibody
SIRT1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western Blot, IHC, ICC/IF, Flow Cytometry, ELISA 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 Protein A 정제, 1 mg/mL 농도, 안정적 액상 형태.
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Thermo Fisher Scientific SIRT1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human SIRT1, amino acids 101–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and promotes changes in histone and DNA methylation, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and mediates the inhibitory effect on skeletal myoblast differentiation under low nutrient conditions, involving AMPK and NAMPT pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: BS-0921R_SIRT1_Q96EB6-1_Rabbit.svg, BS-0921R_SIRT1_Q96EB6-1_Rabbit_PDP.jpeg)
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배송/결제/교환/반품 안내
배송 정보
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