ELK Biotechnology LRP6 rabbit pAb

제품명

LRP6 rabbit pAb

공급업체

ELK Biotechnology

제품 설명

LRP6 rabbit pAb는 인간 LRP6 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. Wnt/β-catenin 신호전달 경로 연구 및 세포막 단백질 분석에 사용됩니다.

제품 스펙

세포 내 위치

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum; Membrane raft.
On Wnt signaling, undergoes caveolin- or clathrin-mediated endocytosis and plasma membrane localization.
Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation.
On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes.
Chaperoned to the plasma membrane by MESD (By similarity).

Background

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands.
The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/β-catenin signaling cascade.
Through its interaction with the Wnt/β-catenin signaling cascade, this gene plays a role in the regulation of cell differentiation, proliferation, and migration, and the development of many cancer types.
This protein undergoes gamma-secretase dependent regulated intramembrane proteolysis (RIP) processing, but the precise locations of the cleavage sites have not been determined. (RefSeq, Dec 2009)

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