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ELK Biotechnology SPHK1 rabbit pAb
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SPHK1 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 사용 가능. 사람, 쥐, 생쥐에 반응하며 세포질, 핵, 세포막 등 다양한 위치에서 발현. -20°C에서 1년 보관 가능.
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ELK Biotechnology ES8981-100UL SPHK1 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES8981-50UL SPHK1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology SPHK1 rabbit pAb
ELK Biotechnology SPHK1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SPHK1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 160–240) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kDa |
| GeneID (Human) | 8877 |
| Human Swiss-Prot No. | Q9NYA1 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, Nucleus, Cell membrane, Endosome membrane; Peripheral membrane protein; Membrane (clathrin-coated pit); Cell junction (synapse). Translocated from cytoplasm to plasma membrane in a CIB1-dependent manner (PubMed:19854831). Binds to negatively charged lipid membranes (PubMed:24929359). Recruited to endocytic membranes by sphingosine to promote membrane fusion (By similarity). |
Background
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it acts as a ligand for G protein-coupled receptors. This protein and its product S1P play key roles in TNF-alpha signaling and NF-kappa-B activation pathways, which are important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Sep 2011).
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