ELK Biotechnology MBP rabbit pAb

제품명

MBP rabbit pAb

제품 설명

MBP rabbit pAb는 인간 단백질에서 유래한 합성 펩타이드를 면역원으로 사용하여 제작된 다클론 항체입니다. 주로 신경계의 수초 단백질 연구에 활용되며, Western blot(WB) 및 ELISA 분석에 적합합니다.

제품 정보

Background

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (also called Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons.
Alternative splicing from the Golli and MBP transcription start sites gives rise to two sets of MBP-related transcripts and gene products. The Golli mRNAs contain three exons unique to Golli-MBP, spliced in-frame to one or more MBP exons, encoding hybrid proteins that have N-terminal Golli amino acid sequences linked to MBP amino acid sequences.
The second family of transcripts contains only MBP exons and produces the well-characterized myelin basic proteins. This complex gene structure is conserved among species, suggesting functional importance in nervous system biology.