ELK Biotechnology Granzyme B rabbit pAb
Granzyme B rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포자멸 유도 단백질인 Granzyme B를 검출하며, 고순도 IgG 형태로 제공됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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Granzyme B rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Granzyme B rabbit pAb |
| Alternative Names | Granzyme B (EC 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E) |
| Applications | WB, IHC, IF, ELISA |
| Recommended Dilutions | IHC-p: 1:100–1:300; WB: 1:500–1:2000; ELISA: 1:10000–1:20000 |
| Immunogen | Synthesized peptide derived from human Granzyme B (AA range: 81–130) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kDa |
| Gene ID (Human) | 3002 |
| Human Swiss-Prot No. | P10144 |
| Cellular Localization | Secreted; Cytolytic granule; Delivered into the target cell by perforin (PubMed:20038786) |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.
[Provided by RefSeq, Sep 2016]
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