ELK Biotechnology Claudin 11 Antibody

Claudin 11 Antibody

제품 개요

Claudin 11은 타이트 접합부를 구성하는 막단백질로, 세포 간 장벽 형성 및 세포 극성 유지에 중요한 역할을 합니다. 본 항체는 인간 Claudin 11에서 유래한 합성 펩타이드를 면역원으로 제작된 폴리클로날 항체로, WB 및 ELISA 실험에 적합합니다.

제품 정보

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been described.

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