ELK Biotechnology FKHRL1 rabbit pAb

FKHRL1 rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, cytosol, nucleus, mitochondrion matrix, mitochondrion outer membrane (peripheral membrane protein, cytoplasmic side).
Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, 15084260, 16751106).
Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, 16751106).
Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity).
Translocates in an AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, 29445193).
Serum deprivation increases localization to the nucleus, leading to activation of SOX9 expression and subsequent chondrogenesis (By similarity).

Background

This gene belongs to the forkhead family of transcription factors, characterized by a distinct forkhead domain. It likely functions as a trigger for apoptosis through expression of genes necessary for cell death.
Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
Alternatively spliced transcript variants encoding the same protein have been observed.
[Provided by RefSeq, Jul 2008]