ELK Biotechnology BACE rabbit pAb

BACE rabbit pAb

제품 개요

ELK Biotechnology의 BACE rabbit pAb는 인간 BACE1 단백질을 인식하는 폴리클로날 토끼 항체로, 알츠하이머병 관련 연구에 적합합니다. WB 및 ELISA 분석에 사용되며, 안정적인 단백질 검출 성능을 제공합니다.

제품 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network, endoplasmic reticulum, endosome, cell surface, cytoplasmic vesicle membrane, membrane raft, lysosome, late endosome, early endosome, recycling endosome, axon, dendrite.
Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes, and on the cell surface (PubMed:17425515, PubMed:11466313).
Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine which blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from end.

Background

Beta-secretase 1 (BACE1) Homo sapiens gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease.
This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer’s disease patients.
[provided by RefSeq, Nov 2015]

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