ELK Biotechnology LATS1/2 (Phospho-Thr1079/1041) Antibody
LATS1/2 단백질의 인산화 상태(Thr1079/1041)를 인식하는 항체로, WB와 ELISA에 적합합니다. 세포주기 관련 단백질 연구 및 종양 억제 기전 분석에 활용됩니다. 사람, 생쥐, 랫드에 반응하며, -20°C에서 1년 보관 가능합니다.
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LATS1/2 (Phospho-Thr1079/1041) Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | LATS1/2 (Phospho-Thr1079/1041) Antibody |
| Alternative Names | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1), Large tumor suppressor homolog 1, WARTS protein kinase, h-warts |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:10000–20000 |
| Immunogen | Synthesized phospho peptide derived from human LATS1/2 (Phospho-Thr1079/1041) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140 kDa |
| Gene ID (Human) | 9113 |
| Human Swiss-Prot No. | O95835 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, spindle, midbody. Localizes to centrosomes during interphase and migrates to the mitotic apparatus (spindle pole bodies, mitotic spindle, midbody) during mitosis. |
Background
The protein encoded by this gene is a serine/threonine kinase that localizes to the mitotic apparatus and forms a complex with CDC2 kinase during early mitosis. It is phosphorylated in a cell cycle-dependent manner, with phosphorylation persisting through metaphase. The N-terminal region binds CDC2, forming a complex with reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds its own N-terminal region, suggesting negative regulation via intramolecular binding. Biochemical and genetic studies indicate a tumor suppressor role, supported by knockout mouse models showing development of soft-tissue sarcomas, ovarian stromal tumors, and increased sensitivity to carcinogenic treatment.
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