ELK Biotechnology Akt (Phospho-Ser129) Antibody
인간, 생쥐, 랫트에 반응하는 Akt (Phospho-Ser129) 폴리클로날 항체로, WB 및 ELISA에 적합. 세포 내 Akt1의 인산화 상태 분석에 유용하며, 세포 성장 및 생존 관련 신호전달 연구에 활용 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Akt (Phospho-Ser129) Antibody
Akt (Phospho-Ser129) Antibody
제품 개요
ELK Biotechnology에서 제공하는 Akt (Phospho-Ser129) 항체는 인간 Akt 단백질의 Ser129 인산화 부위를 인식하는 폴리클로날 항체입니다. 세포 신호전달 및 인산화 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Akt (Phospho-Ser129) Antibody |
| Alternative Names | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1), Protein kinase B (PKB), Protein kinase B alpha (PKB alpha), Proto-oncogene c-Akt, RAC-PK-alpha |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:10000–20000 |
| Immunogen | Synthesized phospho peptide derived from human Akt (Phospho-Ser129) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| GeneID (Human) | 207 |
| Human Swiss-Prot No | P31749 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, Nucleus, Cell membrane.
Nucleus after activation by integrin-linked protein kinase 1 (ILK1).
Nuclear translocation is enhanced by interaction with TCL1A.
Phosphorylation on Tyr-176 by TNK2 results in localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to activation, and the activated form translocates to the nucleus.
Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529).
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved fibroblasts. AKT1 and AKT2 are activated by platelet-derived growth factor through phosphatidylinositol 3-kinase.
In the developing nervous system, AKT acts as a critical mediator of growth factor-induced neuronal survival. It suppresses apoptosis by phosphorylating and inactivating components of the apoptotic machinery.
Mutations in this gene are associated with Proteus syndrome. Multiple alternatively spliced transcript variants have been identified for this gene.
[Provided by RefSeq, Jul 2011]
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.