ELK Biotechnology Integrin β7 rabbit pAb
Integrin β7 단백질을 인식하는 토끼 폴리클로날 항체로, WB, ELISA, IHC에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막 단백질 연구 및 면역조직화학 분석에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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Integrin β7 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Integrin β7 rabbit pAb |
| Alternative Names | Integrin beta-7 (Gut homing receptor beta subunit) |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–1:20000 |
| Immunogen | Synthesized peptide derived from human Integrin β7 (AA range: 671–720) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| GeneID (Human) | 3695 |
| Human Swiss-Prot No. | P26010 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion.
Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer’s patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule.
Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
[provided by RefSeq, Sep 2013]
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