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ELK Biotechnology E2F-1 (Acetyl-K125) rabbit pAb
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E2F-1 (Acetyl-K125) rabbit pAb는 인간, 마우스, 랫트 E2F-1 단백질의 아세틸화된 K125 부위를 인식하는 폴리클로날 항체입니다. WB 및 ELISA에 적합하며, 세포주기 조절 연구 및 종양 억제 단백질 분석에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
- 카탈로그번호
- ES8822-xxxxx (2개 옵션)
- 판매단위
- pk
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ELK Biotechnology ES8822-100UL E2F-1 (Acetyl-K125) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES8822-50UL E2F-1 (Acetyl-K125) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology E2F-1 (Acetyl-K125) rabbit pAb
제품명
E2F-1 (Acetyl-K125) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Transcription factor E2F1 (E2F-1), PBR3, Retinoblastoma-associated protein 1 (RBAP-1), Retinoblastoma-binding protein 3 (RBBP-3), pRB-binding protein E2F-1 |
| Applications | WB, ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized Acetyl peptide derived from human E2F-1 at AA range: K125 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 1869 |
| Human Swiss-Prot No | Q01094 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human: K125; Mouse: K120; Rat: K123 |
배경 (Background)
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of the cell cycle and the action of tumor suppressor proteins, and is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain several evolutionally conserved domains, including:
- DNA binding domain
- Dimerization domain (interacts with DP transcription factors)
- Transactivation domain enriched in acidic amino acids
- Tumor suppressor protein association domain embedded within the transactivation domain
E2F1, along with E2F2 and E2F3, has an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner.
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