ELK Biotechnology TTN rabbit pAb
Titin 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 인체 유래 합성 펩타이드(AA 161-210)를 면역원으로 제작. 세포질과 핵에 발현되는 TTN 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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ELK Biotechnology TTN rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TTN rabbit pAb |
| Alternative Names | Titin (EC 2.7.11.1; Connectin; Rhabdomyosarcoma antigen MU-RMS-40.14) |
| Applications | IHC, IF, ELISA |
| Recommended Dilutions | IHC-p: 1:50–200, ELISA: 1:10000–20000 |
| Immunogen | Synthetic peptide from human protein at AA range: 161–210 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 7273 |
| Human Swiss-Prot No. | Q8WZ42 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, an N-terminal I-band and a C-terminal A-band.
The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine, and lysine.
The A-band, which is thought to act as a protein ruler, contains a mixture of immunoglobulin and fibronectin repeats and possesses kinase activity.
An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere.
Titin also contains binding sites for muscle-associated proteins, serving as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.
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