ELK Biotechnology TGFβ2 rabbit pAb
TGFβ2 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드(AA 361-410)로 면역화. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
TGFβ2 rabbit pAb
대체 명칭
Transforming growth factor beta-2 (TGF-beta-2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Polyergin)
적용 분야
WB, IHC, IF, ELISA
권장 희석 배율
- WB: 1:500–2000
- IHC-p: 1:500–200
- ELISA: 1:10000–20000
면역원
합성된 인간 TGF beta2 유래 펩타이드 (AA range: 361–410)
보관 및 안정성
- 종: Rabbit
- 보관 조건: -20°C, 1년 안정
항체 정보
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| 농도 | 1 mg/ml |
| 관찰된 밴드 | 47 + 12 kD |
| Gene ID (Human) | 7042 |
| Human Swiss-Prot No | P61812 |
| 세포 내 위치 | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix; [Transforming growth factor beta-2]: Secreted |
| 반응 종 | Human, Mouse, Rat |
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior segment of the eye.
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