ELK Biotechnology CKR-1 rabbit pAb

제품명

CKR-1 rabbit pAb

대체 명칭

C-C chemokine receptor type 1 (C-C CKR-1; CC-CKR-1; CCR-1; CCR1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD antigen CD191)

적용 분야

• IHC
• IF
• ELISA

권장 희석 배율

• IHC-p: 1:50–200
• ELISA: 1:10000–20000

면역원

Synthetic peptide from human protein (AA range: 151–200)

저장 조건

-20°C / 1년

항체 정보

유전자 및 단백질 정보

반응 종

Human, Rat, Mouse

배경 정보

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]