ELK Biotechnology CD158k rabbit pAb
CD158k(KIR3DL2) 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 세포막 단백질 검출에 적합하며, 인간·쥐·마우스 시료에 반응. -20°C 보관 시 1년 안정.
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제품명
CD158k rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K; MHC class I NK cell receptor; Natural killer-associated transcript 4; NKAT-4; p70 natural killer cell receptor clone CL-5; p70 NK receptor CL-5; CD antigen CD158k) |
| Applications | IHC, IF, ELISA |
| Recommended Dilutions | IHC-p: 1:50–200, ELISA: 1:10000–20000 |
| Immunogen | Synthetic peptide from human protein (AA 221–270) |
| Host Species | Rabbit |
| Storage Conditions | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 3812 |
| Human Swiss-Prot No. | P43630 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human, Rat, Mouse |
Background
Killer cell immunoglobulin-like receptor, three Ig domains and long cytoplasmic tail 2 (KIR3DL2) is a transmembrane glycoprotein expressed by natural killer (NK) cells and subsets of T cells.
KIR genes are polymorphic and highly homologous, located on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
The KIR gene cluster varies among haplotypes, but several framework genes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) are common to all.
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by the length of their cytoplasmic domain (long, L; or short, S).
Proteins with a long cytoplasmic domain mediate inhibitory signals through an immune tyrosine-based inhibitory motif (ITIM), whereas those with a short domain lack this motif.
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