ELK Biotechnology MLL rabbit pAb
MLL rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체로, 핵 내 MLL 단백질을 검출합니다. WB, IHC, IF, ELISA에 사용 가능하며, H3K4 메틸전이효소 활성을 가진 MLL 단백질 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology MLL rabbit pAb
제품 개요
MLL rabbit pAb는 인간 MLL 단백질을 인식하는 폴리클로날 항체로, 세포핵 내 위치하는 전사 조절 단백질의 연구에 사용됩니다. 이 항체는 다양한 응용 분야(WB, IHC, IF, ELISA)에 적합하며, 인간, 마우스, 랫트에서 반응성을 보입니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | MLL rabbit pAb |
| Alternative Names | Histone-lysine N-methyltransferase MLL (EC 2.1.1.43; ALL-1; CXXC-type zinc finger protein 7; Lysine N-methyltransferase 2A; KMT2A; Trithorax-like protein; Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa; p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa; p180)] |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthetic peptide from human protein at AA range: 3850-3900 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4297 |
| Human Swiss-Prot No | Q03164 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus; [MLL cleavage product N320]: Nucleus; [MLL cleavage product C180]: Nucleus. Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320. |
Background
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains, including the SET domain responsible for histone H3 lysine 4 (H3K4) methyltransferase activity, mediating chromatin modifications associated with epigenetic transcriptional activation. The protein is processed by Taspase 1 into two fragments, MLL-C and MLL-N, which reassociate and form multiprotein complexes regulating transcription of specific target genes such as HOX genes. Chromosomal translocations involving this gene are implicated in certain acute lymphoid and myeloid leukemias. Alternate splicing results in multiple transcript variants.
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