ELK Biotechnology E2F-1 rabbit pAb
E2F-1 단백질을 인식하는 토끼 폴리클로날 항체로, 세포주기 조절 및 종양 억제 단백질 연구에 적합합니다. IF, WB, IHC, ELISA 등 다양한 응용에 사용 가능하며, 인체 유래 합성 펩타이드로 면역화되었습니다. 핵 내 단백질 검출에 최적화되어 있습니다.
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E2F-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | E2F-1 rabbit pAb |
| Alternative Names | E2F1, RBBP3 |
| Applications | IF, WB, IHC, ELISA |
| Recommended Dilutions | IF: 1:50–200; WB: 1:500–2000; ELISA: 1:10000–20000; IHC: 1:50–300 |
| Immunogen | Synthetic peptide from human protein (AA range: 100–170) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| Gene ID (Human) | 1869 |
| Human Swiss-Prot No. | Q01094 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of the cell cycle and the action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. E2F proteins contain several evolutionarily conserved domains, including a DNA-binding domain, a dimerization domain for interaction with DP proteins, a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain embedded within the transactivation domain. E2F1, along with E2F2 and E2F3, has an additional cyclin-binding domain and binds preferentially to the retinoblastoma protein (pRB) in a cell-cycle-dependent manner.
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