ELK Biotechnology Amyloid-β rabbit pAb
Amyloid-β 단백질을 인식하는 토끼 폴리클로날 항체로, Alzheimer 관련 연구에 적합. WB, IF, ELISA 등 다양한 응용 가능. 고순도 IgG 형태로 -20°C에서 장기 보관 가능. Human, Rat, Mouse 반응성 확인됨.
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Amyloid-β rabbit pAb
Supplier: ELK Biotechnology
제품 개요
Amyloid-β rabbit pAb는 알츠하이머병 관련 단백질 연구에 사용되는 고품질 폴리클로날 항체입니다. Amyloid beta A4 protein을 인식하며, 다양한 실험 응용(WB, IF, ELISA)에 적합합니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Product Name | Amyloid-β rabbit pAb |
| Alternative Names | Amyloid beta A4 protein (ABPP), APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide (CVAP), PreA4, Protease nexin-II (PN-II) Cleaved into: N-APP, S-APP-alpha, S-APP-beta, C99, Beta-APP42, Beta-APP40, C83, P3(42), P3(40), C80, AICD-59, AICD-57, AICD-50, C31 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | WB 1:500–2000; IF/ICC 1:100–500; ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from Amyloid-β (AA range: 631–680) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 86 + 45 kD |
| GeneID (Human) | 351 |
| Human Swiss-Prot No | P05067 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Perikaryon; Growth cone; Clathrin-coated pit; Early endosome; Cytoplasmic vesicle. Most protein localized in intracellular vesicles. During maturation, APP moves from ER to Golgi for complete glycosylation and sulfation. After α-secretase cleavage, soluble APP is released extracellularly, and C-terminal fragment internalized to endosomes and lysosomes. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a transmembrane precursor protein that is cleaved by secretases to form multiple peptides. Some peptides promote transcriptional activation via APBB1/TIP60, while others form amyloid plaques characteristic of Alzheimer’s disease. Certain peptides exhibit antimicrobial activity. Mutations are associated with autosomal dominant Alzheimer disease and cerebral amyloid angiopathy. Multiple transcript variants exist. (RefSeq, Aug 2014)
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