Thermo Fisher Scientific DKC1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DKC1 protein. Validated for WB and IP applications. Predicted cross-reactivity with mouse, rat, Drosophila, and chicken. Affinity-purified, unconjugated form in TBS buffer with BSA and sodium azide. For resear...
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 5–15 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 340 and 390 of human dyskeratosis congenita 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Rat, D. melanogaster, and Chicken
Target Information
This gene belongs to the H/ACA snoRNPs family, which is involved in rRNA processing and modification. H/ACA snoRNPs include NOLA1, NOLA2, and NOLA3 proteins. The encoded protein and NOLA proteins localize to nucleoli and coiled bodies in the nucleus. Depletion of any one of these proteins impairs 18S rRNA production and rRNA pseudouridylation. These proteins are also components of the telomerase complex.
The DKC1 gene is related to Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. It is transcribed in a telomere-to-centromere direction and mutations in this gene cause X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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