Thermo Fisher Scientific NHLRC1 Polyclonal Antibody
Rabbit polyclonal antibody against human NHLRC1 protein. Validated for IHC (Paraffin) and ELISA. Recognizes recombinant E3 ubiquitin-protein ligase NHLRC1 (86–395aa). Supplied in PBS with 50% glycerol, stored at -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | – |
| ELISA | Assay-dependent | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (86–395aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.63 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2915013 |
Product Specific Information
Antibody tested in Indirect ELISA.
Target Information
Progressive myoclonic epilepsy type 2 (EPM2), also known as Lafora disease, is an autosomal recessive disorder characterized by grand mal seizures and/or myoclonus around 15 years of age, followed by rapid mental deterioration with psychotic features. Survival is typically less than 10 years after onset. Lafora bodies—starch-like polyglucosans associated with the endoplasmic reticulum—are found in brain, muscle, liver, and heart.
Mutations in NHLRC1, which encodes the E3 ubiquitin ligase Malin, are one cause of Lafora disease. Malin contains six NHL repeats and one RING-type zinc finger, mediating ubiquitination activity. It interacts with and polyubiquitinates Laforin, another protein implicated in EPM2. Malin localizes mainly to the endoplasmic reticulum and partially in the nucleus, and is expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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