Thermo Fisher Scientific MAPK13 Monoclonal Antibody (OTI12E2), TrueMAB

Applications

• Western Blot (WB): 1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

MAPK13 (p38 delta) is a serine/threonine kinase that transduces extracellular signals such as cytokine and environmental stress responses. It regulates keratinocyte differentiation and is activated by environmental stresses and proinflammatory cytokines. Activation occurs via phosphorylation by MAP kinase kinases or autophosphorylation triggered by interaction with MAP3K7IP1/TAB1.
Substrates include transcription regulators (ATF2, MEF2C, MAX), cell cycle regulator (CDC25B), and tumor suppressor (p53), indicating roles in stress-related transcription, cell cycle regulation, and genotoxic stress response. Four alternatively spliced transcript variants of SAPK4 encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.