Thermo Fisher Scientific Phospho-JAK2/JAK3 (Tyr966, Tyr939) Polyclonal Antibody
JAK2 및 JAK3의 Tyr966, Tyr939 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot에 적합하며, 세포 내 신호전달 연구에 유용. Rabbit IgG 기반 액상형 비결합 항체로, -20°C 보관.
- 카탈로그번호
- PA564587
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK2/3 (Phospho-Tyr966/939) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2662176 |
Product Specific Information
Phospho-JAK2/JAK3 (Tyr966, Tyr939) Polyclonal Antibody detects endogenous levels of JAK2/JAK3 only when phosphorylated at Tyr966, Tyr939.
Target Information
Janus Activating Kinase 2 and 3 (JAK2/JAK3) are tyrosine kinases involved in cytoplasmic signal transduction. Upon stimulation by cytokines or related factors (e.g., interferons, interleukins), JAKs are activated via phosphorylation at adjacent tyrosine residues. Activated JAKs phosphorylate STAT (signal transducers and activators of transcription) proteins, which dimerize, translocate to the nucleus, and regulate transcription of interferon-stimulated genes.
JAK2 is essential for IFN-γ receptor complex initiation, while JAK1 functions as an amplifier. In some contexts, Tyk2 and JAK3 may compensate for JAK2 function depending on complex positioning.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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