Thermo Fisher Scientific Dectin 2 Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 Dectin-2 단백질을 인식합니다. Western blot 및 IHC에 적합하며, 고유의 N-말단 합성 펩타이드로 면역화되었습니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human Dectin-2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Dectin-2.
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 recognizes high mannose structures and mediates cytokine production from dendritic cells and other antigen-presenting cells.
Although it lacks obvious signaling motifs, Dectin-2 utilizes FcRγ for internalization and activation of the NF-κB pathway, leading to cytokine production. It shares 20–25% homology with Dectin-1 but functions similarly as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk-CARD9 pathway) and adaptive immune responses through dendritic cell activation.
Thus, Dectin-2 serves as a connector molecule between innate and adaptive immunity at the dendritic cell level.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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