Thermo Fisher Scientific AVEN Polyclonal Antibody
다중 종에 반응하는 Rabbit Polyclonal 항체로 Apoptosis 관련 Aven 단백질 검출에 적합. Western blot, ICC/IF, Flow cytometry 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Thermo Fisher Scientific AVEN Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:200 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues at the carboxy terminus of Aven |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 40 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987020 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer.
Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation.
Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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