Thermo Fisher Scientific EDG6 Polyclonal Antibody

Thermo Fisher Scientific EDG6 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 8 µg/mL

Product Specifications

Product Specific Information

PA1-20778 detects S1P4 in human samples.

Target Information

EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate.
There are eight known members of the EDG receptor family, implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis.
They also evoke cellular effector functions dependent on cytoskeletal responses such as contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases.
EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.
Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.