Thermo Fisher Scientific COX1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human COX1. Recombinant protein control fragment (Product #RP-99360). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:COX1,uniProtId:P23219-1,ncbiNodeId:9606,antigenRange:390-536,antigenLength:599,antigenImageFileName:PA5-110660_COX1_P23219-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110660_COX1_P23219-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2856071

Product Specific Information

Immunogen sequence: MPDSFKVGSQ EYSYEQFLFN TSMLVDYGVE ALVDAFSRQI AGRIGGGRNM DHHILHVAVD VIRESREMRL QPFNEYRKRF GMKPYTSFQE LVGEKEMAAE LEELYGDIDA LEFYPGLLLE KCHPNSIFGE SMIEIGAPFS LKGLLGN

Target Information

PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.