
Thermo Fisher Scientific COX1 Polyclonal Antibody
COX1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 COX1에 반응하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5110660
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COX1 (Product #RP-99360) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856071 |
Product Specific Information
Immunogen sequence:
MPDSFKVGSQ EYSYEQFLFN TSMLVDYGVE ALVDAFSRQI AGRIGGGRNM DHHILHVAVD VIRESREMRL QPFNEYRKRF GMKPYTSFQE LVGEKEMAAE LEELYGDIDA LEFYPGLLLE KCHPNSIFGE SMIEIGAPFS LKGLLGN
Target Information
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, acting both as a dioxygenase and a peroxidase. There are two isozymes of PTGS: constitutive PTGS1 and inducible PTGS2, differing in regulation and tissue distribution. PTGS1 regulates angiogenesis in endothelial cells and is inhibited by NSAIDs such as aspirin. It is involved in cell signaling and tissue homeostasis. Alternative splicing generates two transcript variants, differentially regulated by cytokines and growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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