Thermo Fisher Scientific MCK10 Polyclonal Antibody
MCK10(DDR1) 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 다양한 종에 예측 반응성을 보입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 581–795 of Human DDR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.03 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546760 |
Product Specific Information
- Recommended positive control: THP-1
- Predicted reactivity: Mouse (88%), Rat (88%), Pig (97%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DDR1 is a receptor tyrosine kinase activated by collagen and regulates adhesion, cell migration, and other cellular processes. Receptor tyrosine kinases (RTKs) are key mediators of cell communication with the microenvironment and regulate cell growth, differentiation, and metabolism.
DDR1 is widely expressed in epithelial cells and activated by multiple collagen types (I–VI). Expression is prominent in kidney, lung, gastrointestinal tract, and brain, and is overexpressed in several human tumors (breast, ovarian, esophageal, pediatric brain).
The DDR1 gene is located on chromosome 6p21.3 near HLA class I genes, with multiple transcript variants generated by alternative splicing.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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