Thermo Fisher Scientific MSL2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human MSL2. Recombinant protein control fragment (Product #RP-104856). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MSL2,uniProtId:Q9HCI7-1,ncbiNodeId:9606,antigenRange:431-571,antigenLength:577,antigenImageFileName:PA5-65518_MSL2_Q9HCI7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65518_MSL2_Q9HCI7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664842

Product Specific Information

Immunogen sequence: DKAVKEKIPSH HFMPGSPTKT VYKKPQEKKG CKCGRATQNP SVLTCRGQRC PCYSNRKACL DCICRGCQNS YMANGEKKLE AFAVPEKALE QTRLTLGINV TSIAVRNAST STSVINVTGS PVTTFLAAST HDDKSLDEAI

Highest antigen sequence identity to the following orthologs - mouse 99%, rat 100%.

Target Information

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.