Thermo Fisher Scientific TPPP Polyclonal Antibody
TPPP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot에 적합합니다. Human, Mouse, Rat 반응성을 가지며 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충용액에 보관되며 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 27–219 of Human TPPP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.87 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548965 |
Product Specific Information
- Recommended positive controls: mouse brain, PC-12, Rat2, rat brain
- Predicted reactivity: Mouse (94%), Rat (94%), Pig (96%), Rhesus Monkey (100%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis, and vesicle transport.
TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm.
TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. Overexpression of TPPP prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope.
TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome.
It may play a role in the polymerization of tubulin into microtubules, microtubule bundling, and stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. It may also play a role in mitotic spindle assembly and nuclear envelope breakdown.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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