Thermo Fisher Scientific TPPP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:20,000

Product Specifications

Product Specific Information

• Recommended positive controls: mouse brain, PC-12, Rat2, rat brain
• Predicted reactivity: Mouse (94%), Rat (94%), Pig (96%), Rhesus Monkey (100%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis, and vesicle transport.
TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm.
TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. Overexpression of TPPP prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope.
TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome.
It may play a role in the polymerization of tubulin into microtubules, microtubule bundling, and stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. It may also play a role in mitotic spindle assembly and nuclear envelope breakdown.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.